The URSA-II will technically work with HPGe detectors, though it is not ideal for that purpose. The device was designed around detectors such as NaI and CdZnTe, and there is a little bit of jitter in the amplification/ADC. With an HPGe detector, you get peaks a couple of times wider than you would expect. Another consideration is with regard to the HV supply, as the URSA-II can only supply up to 2000V where most of the HPGe detectors require 3000 or more.